Formulation and characterization of poloxamer 407®: thermoreversible gel containing polymeric microparticles and hyaluronic acid

Química Nova

Granada, Jonas Eichelberger¹  Kechinski, Carolina Pereira¹  Pereira, Gabriela Garrastazu¹  Dimer, Frantiescoli Anversa¹  Guterres, Sílvia Stanisçuaki¹  Cardozo, Nilo Sérgio Medeiros¹  Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil¹ 

关键词: thermoreversible gel;    rheology;    burn wounds.;   

DOI  :  10.1590/S0100-40422013000800008

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The influence of the composition and preparation method on the sol-gel transition temperature (Tsol-gel) and rheological response of poloxamer-based formulations was determined. Manual and more complex mechanical stirring were found to provide similar results. In addition, a linear dependence of Tsol-gel on the poloxamer content was observed in the range of concentrations analyzed, and a Poloxamer 407® concentration of 18% was selected. The addition of hyaluronic acid did not lead to significant changes in the Tsol-gel values. In contrast, the addition of microparticles caused a reduction in Tsol-gel without a significant reduction in gel strength, and pseudoplastic characteristics were observed, indicating that a thermoreversible gel was obtained with a rheology suitable for application in the treatment of burn wounds.

【 授权许可】

Unknown