Formulation and characterization of poloxamer 407®: thermoreversible gel containing polymeric microparticles and hyaluronic acid

Química Nova

Gabriela Garrastazu Pereira²  Frantiescoli Anversa Dimer²  Sílvia Stanisçuaki Guterres²  Carolina Pereira Kechinski¹  Jonas Eichelberger Granada¹  Nilo Sérgio Medeiros Cardozo¹ 

[1] ,Universidade Federal do Rio Grande do Sul Faculdade de Farmácia Porto Alegre RS ,Brasil

关键词: thermoreversible gel;    rheology;    burn wounds;   

DOI  :  10.1590/S0100-40422013000800008

来源: SciELO

【 摘 要 】

The influence of the composition and preparation method on the sol-gel transition temperature (Tsol-gel) and rheological response of poloxamer-based formulations was determined. Manual and more complex mechanical stirring were found to provide similar results. In addition, a linear dependence of Tsol-gel on the poloxamer content was observed in the range of concentrations analyzed, and a Poloxamer 407® concentration of 18% was selected. The addition of hyaluronic acid did not lead to significant changes in the Tsol-gel values. In contrast, the addition of microparticles caused a reduction in Tsol-gel without a significant reduction in gel strength, and pseudoplastic characteristics were observed, indicating that a thermoreversible gel was obtained with a rheology suitable for application in the treatment of burn wounds.

【 授权许可】

CC BY-NC   
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