Extraction of polychlorinated biphenyls in breast milk samples: univariated optimization versus experimental design

Química Nova

Kowalski, Cláudia Hoffmann¹  Augusto, Fabio¹  Godoy, Helena Teixeira¹  Universidade Estadual de Campinas, Campinas, Brasil¹ 

关键词: PCBs;    SPME;    Doehlert design.;   

DOI  :  10.1590/S0100-40422013000300018

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The convenience of the multivariate optimization of SPME procedures through ANOVA calculated using Doehlert designs has been demonstrated for twelve PCBs in the complex matrix of milk. For this study, the main parameters of the extraction were selected and valued through univariate and multivariate optimization. In addition, the analysis of variance allowed identification of the statistically significant variables in this model: high temperature (95 ºC) and ionic strength (36% m/v) proved significant for all the PCBs while intermediate time (70 min) and low methanol concentration (5% v/v) also contributed to the extraction of the majority of these PCBs.

【 授权许可】

Unknown