Characterization and in vitro release of cyclosporine-A from poly(D,L-lactide-co-glycolide implants obtained by solvent/extraction evaporation

Química Nova

Silva, Gisele Rodrigues da¹  Universidade Federal de São João Del Rei, Divinópolis, Brasil¹  Mansur, Alexandra Ancelmo Piscitelli¹  Silva-Cunha Junior, Armando da¹  Yoshida, Maria Irene¹  Saliba, Juliana Barbosa¹  Universidade Federal de Minas Gerais, Belo Horizonte, Brasil¹  Mansur, Herman Sander¹ 

关键词: cyclosporine-A;    poly(D;    L–lactide–co–glycolide) (PLGA);    biodegradable intraocular implant.;   

DOI  :  10.1590/S0100-40422012000400013

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Cyclosporine-A-loaded PLGA implants were developed intended for ocular route. Implants were prepared using solvent extraction/evaporation technique followed by casting of the cake into rods in a heated surface. XRD patterns showed that cyclosporine-A was completely incorporated into PLGA. FTIR and DSC results indicated alterations on drug molecular conformation aiming to reach the most stable thermodynamic conformation at polymer/drug interface. Implants provided controlled/sustained in vitro release of the drug. During the first 7 weeks, the drug release was controlled by the diffusion of the cyclosporine-A; and between 7-23 week period, the drug diffusion and degradation of PLGA controlled the drug release.

【 授权许可】

Unknown