Development and application of methods for the determination of ivermectin in veterinarian medications

Química Nova

Costa, Fabio Macedo da¹  Universidade Federal Fluminense, Niterói, Brasil¹  Pereira Netto, Annibal Duarte¹ 

关键词: Ivermectin;    HPLC-UV;    absorption spectrometry.;   

DOI  :  10.1590/S0100-40422012000300031

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Two methods for the determination of Ivermectin in veterinarian medications were developed and compared. One of the methods was based on UV spectrometry and the other on HPLC-UV. The former method was shown to be positively biased regarding the nominal concentrations of Ivermectin in different medications. The method of standard addition was unable to correct this bias, indicating significant matrix effects. The HPLC-UV method showed good linearity, throughput, recovery and limits of detection and quantitation adequate for its application in the evaluation of Ivermectin in medications. Several medications were evaluated and good agreement between our results and their nominal concentrations was found.

【 授权许可】

Unknown