Development and application of methods for the determination of ivermectin in veterinarian medications

Quimica nova

Costa, Fabio Macedo da¹  Pereira Netto, Annibal Duarte¹ 

[1] Universidade Federal Fluminense, Niterói, Brasil

关键词: Ivermectin;    HPLC-UV;    absorption spectrometry.;   

DOI  :  10.1590/S0100-40422012000300031

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Two methods forthe determination of Ivermectin in veterinarian medications were developed andcompared. One of the methods was based on UV spectrometry and the other on HPLC-UV.The former method was shown to be positively biased regarding the nominal concentrationsof Ivermectin in different medications. The method of standard addition wasunable to correct this bias, indicating significant matrix effects. The HPLC-UVmethod showed good linearity, throughput, recovery and limits of detection andquantitation adequate for its application in the evaluation of Ivermectin inmedications. Several medications were evaluated and good agreement between ourresults and their nominal concentrations was found.

【 授权许可】

CC BY