Química Nova | |
Derivative spectrophotometric method for determination of acyclovir in polymeric nanoparticles | |
Tavares, Guilherme Diniz1  Kedor-Hackmann, Érika Rosa Maria1  Consiglieri, Vladi Olga1  Universidade de São Paulo, São Paulo, Brasil1  Ishikawa, Gisele Miki1  Monteiro, Talita Ferreira1  Zanolini, Carolina1  Bou-Chacra, Nádia Araci1  | |
关键词: acyclovir; polymeric nanoparticles; derivative spectrophotometry.; | |
DOI : 10.1590/S0100-40422012000100035 | |
学科分类:化学(综合) | |
来源: Sociedade Brasileira de Quimica | |
【 摘 要 】
A derivative spectrophotometric method was validated for quantification of acyclovir in poly (n-butylcyanoacrylate) (PBCA) nanoparticles. Specificity, linearity, precision, accuracy, recovery, detection (LOD) and quantification (LOQ) limits were established for method validation. First-derivative at 295.2 nm eliminated interferences from nanoparticle ingredients and presented linearity for acyclovir concentrations ranging from 1.25 to 40.0 µg/mL (r = 0.9999). Precision and accuracy data demonstrated good reproducibility. Recovery ranged from 99.3 to 101.2. LOD was 0.08 µg/mL and LOQ, 0.25 µg/mL. Thus, the proposed method proved to be easy, low cost, and accurate, and therefore, an useful alternative to quantify acyclovir in nanoparticles.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912050595515ZK.pdf | 522KB | download |