Development and validation of an UV spectrophotometric method for the determination of aliskiren in tablets

Química Nova

Diefenbach, Isabel Fração¹  Rolim, Clarice Madalena Bueno¹  Sangoi, Maximiliano da Silva¹  Secretti, Leonardo Trevisan¹  Universidade Federal de Santa Maria, Santa Maria, Brasil¹  Wrasse-Sangoi, Micheli¹  Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil¹ 

关键词: aliskiren;    pharmaceutical formulation;    UV spectrophotometry.;   

DOI  :  10.1590/S0100-40422010000600021

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

For determination of aliskiren in commercial samples, an analytical UV spectrophotometric method was developed and validate according to ICH guideline. The method was linear in the range between 40 and 100 μg mL-1 (r2 = 0.9997, n = 7) and exhibited suitable specificity, accuracy, precision, and robustness. It is simple, it has low cost, and it has low use polluting reagents. Therefore, the proposed method was successfully applied for the assay and dissolution studies of aliskiren in tablet dosage forms, and the results were compared to a validated RP-LC method, showing non-significant difference (P > 0.05).

【 授权许可】

Unknown