Development and validation of an UV spectrophotometric method for the determination of aliskiren in tablets

Química Nova

Micheli Wrasse-sangoi²  Leonardo Trevisan Secretti²  Isabel Fração Diefenbach²  Clarice Madalena Bueno Rolim²  Maximiliano Da Silva Sangoi¹ 

[1],Universidade Federal de Santa Maria Departamento de Farmácia Industrial Santa Maria RS ,Brasil

关键词: aliskiren;    pharmaceutical formulation;    UV spectrophotometry;   

DOI  :  10.1590/S0100-40422010000600021

来源: SciELO

【 摘 要 】

For determination of aliskiren in commercial samples, an analytical UV spectrophotometric method was developed and validate according to ICH guideline. The method was linear in the range between 40 and 100 μg mL-1 (r² = 0.9997, n = 7) and exhibited suitable specificity, accuracy, precision, and robustness. It is simple, it has low cost, and it has low use polluting reagents. Therefore, the proposed method was successfully applied for the assay and dissolution studies of aliskiren in tablet dosage forms, and the results were compared to a validated RP-LC method, showing non-significant difference (P > 0.05).

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License