Validation of a simple and rapid UV spectrophotometric method for dexamethasone assay in tablets

Química Nova

Rolim, Clarice Madalena Bueno¹  Beck, Ruy Carlos Ruver¹  Friedrich, Rossana Barcellos¹  Universidade Federal de Santa Maria, Santa Maria, Brasil¹  Cichota, Luiz Carlos¹  Ravanello, Aline¹ 

关键词: dexamethasone;    tablets;    UV spectrophotometry.;   

DOI  :  10.1590/S0100-40422009000400038

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

This work reports the validation of an analytical UV spectrophotometric method to assay dexamethasone in tablets (assay and dissolution studies). The method was linear in the range between 1 and 30 µg mL-1 presenting a good correlation coefficient (r = 0.9998, n = 7). Precision and accuracy analysis showed low relative standard deviation (< 2.00%) and good percentual recoveries (95-105%). The procedure was linear, accurate, precise, and robust. The method is simple, and it has low cost. It does not use polluting reagents and can be applied in dissolution studies, being an adequate alternative to assay dexamethasone in tablets.

【 授权许可】

Unknown