Validation of a simple and rapid UV spectrophotometric method for dexamethasone assay in tablets

Quimica nova

Rolim, Clarice Madalena Bueno¹  Beck, Ruy Carlos Ruver¹  Friedrich, Rossana Barcellos¹  Cichota, Luiz Carlos¹  Ravanello, Aline¹ 

[1] Universidade Federal de Santa Maria, Santa Maria, Brasil

关键词: dexamethasone;    tablets;    UV spectrophotometry.;   

DOI  :  10.1590/S0100-40422009000400038

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

This work reportsthe validation of an analytical UV spectrophotometric method to assay dexamethasonein tablets (assay and dissolution studies). The method was linear in the rangebetween 1 and 30 µg mL-1 presenting a good correlation coefficient(r = 0.9998, n = 7). Precision and accuracy analysis showed low relative standarddeviation (< 2.00%) and good percentual recoveries (95-105%). The procedurewas linear, accurate, precise, and robust. The method is simple, and it haslow cost. It does not use polluting reagents and can be applied in dissolutionstudies, being an adequate alternative to assay dexamethasone in tablets.

【 授权许可】

CC BY