Development and physicochemical characterization of dexamethasone-loaded polymeric nanocapsule suspensions

Química Nova

Fontana, Marcia Camponogara¹  Beck, Ruy Carlos R.¹  Friedrich, Rossana Barcellos¹  Pohlmann, Adriana Raffin¹  Universidade Federal de Santa Maria, Santa Maria, Brasil¹  Guterres, Silvia Stanisçuaski¹  Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil¹ 

关键词: dexamethasone;    nanocapsules;    nanoparticles.;   

DOI  :  10.1590/S0100-40422008000500038

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The influence of drug concentration, oil phase, and surfactants on the characteristics of dexamethasone-loaded nanocapsules was investigated. The best formulations were obtained at dexamethasone concentrations of 0.25 and 0.50 mg.mL-1 (encapsulation efficiency: 80-90%; mean size: 189–253 nm). The type of oil phase influenced only the stability of dexamethasone-loaded nanocapsules. The association of polysorbate 80 and sorbitan monooleate provided a more stable formulation. Sunflower oil and sorbitan sesquioleate used for the first time as oil phase and surfactant for nanocapsules, respectively, have allowed obtaining suspensions with low mean size and narrow size distribution.

【 授权许可】

Unknown