Development and physicochemical characterization of dexamethasone-loaded polymeric nanocapsule suspensions

Quimica nova

Fontana, Marcia Camponogara¹  Friedrich, Rossana Barcellos¹  Beck, Ruy Carlos R.¹  Pohlmann, Adriana Raffin²  Guterres, Silvia Stanisçuaski² 

[1] Universidade Federal de Santa Maria, Santa Maria, Brasil;Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil

关键词: dexamethasone;    nanocapsules;    nanoparticles.;   

DOI  :  10.1590/S0100-40422008000500038

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The influence of drug concentration, oil phase,and surfactants on the characteristics of dexamethasone-loaded nanocapsuleswas investigated. The best formulations were obtained at dexamethasone concentrationsof 0.25 and 0.50 mg.mL-1 (encapsulation efficiency: 80-90%; meansize: 189–253 nm). The type of oil phase influenced only the stabilityof dexamethasone-loaded nanocapsules. The association of polysorbate 80 andsorbitan monooleate provided a more stable formulation. Sunflower oil and sorbitansesquioleate used for the first time as oil phase and surfactant for nanocapsules,respectively, have allowed obtaining suspensions with low mean size and narrowsize distribution.

【 授权许可】

CC BY