Quimica nova | |
Development and physicochemical characterization of dexamethasone-loaded polymeric nanocapsule suspensions | |
Fontana, Marcia Camponogara1  Friedrich, Rossana Barcellos1  Beck, Ruy Carlos R.1  Pohlmann, Adriana Raffin2  Guterres, Silvia Stanisçuaski2  | |
[1] Universidade Federal de Santa Maria, Santa Maria, Brasil;Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil | |
关键词: dexamethasone; nanocapsules; nanoparticles.; | |
DOI : 10.1590/S0100-40422008000500038 | |
学科分类:化学(综合) | |
来源: Sociedade Brasileira de Quimica | |
【 摘 要 】
The influence of drug concentration, oil phase,and surfactants on the characteristics of dexamethasone-loaded nanocapsuleswas investigated. The best formulations were obtained at dexamethasone concentrationsof 0.25 and 0.50 mg.mL-1 (encapsulation efficiency: 80-90%; meansize: 189253 nm). The type of oil phase influenced only the stabilityof dexamethasone-loaded nanocapsules. The association of polysorbate 80 andsorbitan monooleate provided a more stable formulation. Sunflower oil and sorbitansesquioleate used for the first time as oil phase and surfactant for nanocapsules,respectively, have allowed obtaining suspensions with low mean size and narrowsize distribution.
【 授权许可】
CC BY
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201902014763633ZK.pdf | 70KB | download |