The influence of chondroitin sulfate in the formation of isolated polymethacrylate films: evaluation of swelling index and permeability to water vapor

Química Nova

Universidade Estadual do Oeste do Paraná, Cascavel, Brasil¹  Bunhak, Élcio José¹  Mendes, Elisabete Scolin¹  Universidade Estadual de Maringá, Maringá, Brasil¹  Cavalcanti, Osvaldo Albuquerque¹  Pereira, Nehemias Curvelo¹ 

关键词: polymeric association;    chondroitin sulfate;    permeability.;   

DOI  :  10.1590/S0100-40422007000200014

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Natural or modified chondroitin sulfate was incorporated in to polymethacrylate to obtain isolated films. The addition of polysaccharide to synthetic polymers occurred at different rates. Isolated films were micro and macroscopically characterized and swelling index and water vapor transmission were determined. Results indicated changed transparency and flexibility, coupled to their dependence on increase in polysaccharide concentration. A similar occurrence was reported in the permeability to water vapor and swelling degree. Films composed of modified chondroitin sulfate, 90:10 concentration, showed hydration levels, permeability and morphological properties which allow them to be applied as excipients in the development of new drug delivery systems.

【 授权许可】

Unknown