Nanoparticle-coated organic-inorganic microparticles: experimental design and gastrointestinal tolerance evaluation

Química Nova

Haas, Sandra Elisa¹  Instituto de Pesquisas Tecnológicas do Estado de São Paulo, São Paulo, Brazil¹  Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil¹  Beck, Ruy Carlos R.¹  Benvenutti, Edilson V.¹  Pohlmann, Adriana Raffin¹  Guterres, Silvia Stanisçuaski¹  Ré, Maria Inês¹ 

关键词: nanocoating;    nanoparticle;    microparticle.;   

DOI  :  10.1590/S0100-40422006000500019

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The influences of the spray-drying parameters and the type of nanoparticles (nanocapsules or nanospheres) on the characteristics of nanoparticle-coated diclofenac-loaded microparticles were investigated by using a factorial design 32. Gastrointestinal tolerance following oral administration in rats was evaluated. Formulations were selected considering the best yields, the best encapsulation efficiencies and the lowest water contents, presenting surfaces completely coated by nanostructures and a decrease in the surface areas in relation to the uncoated core. In vitro drug release demonstrated the influence of the nanoparticle-coating on the dissolution profiles of diclofenac. Nanocapsule-coated microparticles presented a protective effect on the gastrointestinal mucosa.

【 授权许可】

Unknown