Nanoparticle-coated organic-inorganic microparticles: experimental design and gastrointestinal tolerance evaluation

Quimica nova

Ré, Maria Inês¹  Haas, Sandra Elisa²  Beck, Ruy Carlos R.²  Benvenutti, Edilson V.²  Pohlmann, Adriana Raffin²  Guterres, Silvia Stanisçuaski² 

[1] Instituto de Pesquisas Tecnológicas do Estado de São Paulo, São Paulo, Brazil;Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

关键词: nanocoating;    nanoparticle;    microparticle.;   

DOI  :  10.1590/S0100-40422006000500019

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The influencesof the spray-drying parameters and the type of nanoparticles (nanocapsules ornanospheres) on the characteristics of nanoparticle-coated diclofenac-loadedmicroparticles were investigated by using a factorial design 32.Gastrointestinal tolerance following oral administration in rats was evaluated.Formulations were selected considering the best yields, the best encapsulationefficiencies and the lowest water contents, presenting surfaces completely coatedby nanostructures and a decrease in the surface areas in relation to the uncoatedcore. In vitro drug release demonstrated the influence of the nanoparticle-coatingon the dissolution profiles of diclofenac. Nanocapsule-coated microparticlespresented a protective effect on the gastrointestinal mucosa.

【 授权许可】

CC BY