Meroterpenoid Hydroquinones from Cordia globosa

Journal of the Brazilian Chemical Society

Braz-Filho, Raimundo¹  Lima, Karisia S. B. de¹  Pessoa, Otilia Deusdênia L.¹  Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Brazil¹  Pinto, Francisco das Chagas L.¹  Universidade Federal do Ceará, Fortaleza, Brazil¹  Oliveira, André Luis L. de¹  Silva, Ana Karine O.¹  Silveira, Edilberto R.¹ 

关键词:  Cordia globosa;    Boraginaceae;    hydroquinones;   

DOI  :  10.5935/0103-5053.20150278

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

Two new meroterpenoid hydroquinones,rel-(4bE,6Z,8E,9aS,10S)-1,4-dihydroxy-9a,10-dihydro-10,12-epoxy-5-methylbenzo[a]azulen-12-one andrel-(4bZ,6Z,8E,9aS,10S)-1-hydroxy-9a,10-dihydro-4,11:10,12-diepoxy-benzo[a]azulen-11,12-dione, along with the known peptide derivative (S)-N-benzoylphenylalanine-(S)-2-benzamide-3-phenylpropyl ester, were isolated from the roots of Cordia globosa. Their structures were determined by 1D and 2D nuclear magnetic resonance (NMR) spectrometry, Fourier transform infrared (FTIR) spectroscopy and high resolution atmospheric pressure chemical ionization mass spectrometry (HRAPCIMS) data analysis. The new compounds were tested against three human cancer cell lines (colon adenocarcinoma, ovarian carcinoma and glioblastoma), but none of them exhibited any activity.

【 授权许可】

Unknown