Synthesis and antioxidant activity of 1,4-[bis(3-arylmethanesulfonyl pyrrolyl and pyrazolyl)]benzenes

Journal of the Brazilian Chemical Society

Padmavathi, Venkatapuram¹  Lavanya, Gopala¹  Padmaja, Adivireddy¹  Sri Venkateswara University, Tirupati, India¹ 

关键词: Michael acceptor;    pyrrole;    pyrazoline;    pyrazole;    antioxidant activity;   

DOI  :  10.5935/0103-5053.20140097

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

A variety of (1,4-phenylene)bis(arylmethanesulfonylpyrroles and pyrazoles) were prepared by the cycloaddition of 1,3-dipolar reagents, tosylmethyl isocyanide and diazomethane to the Michael acceptor, 1,4-bis(E)-2-((arylmethanesulfonyl)vinyl)benzene. All the compounds were evaluated for antioxidant activity. Amongst the tested compounds, one of them displayed excellent radical scavenging activity in all the three methods evaluated when compared with the standard Ascorbic acid. On the other hand, 1,4-(bis(3-arylmethanesulfonyl)-1H-pyrazol-4-yl)benzenes exhibited comparatively higher antioxidant activity than 1,4-(bis(3-arylmethanesulfonyl)-1H-pyrrol-4-yl)benzenes. In general, it was observed that compounds having methoxy substitutent on aromatic ring displayed greater antioxidant activity than the other substituents.

【 授权许可】

Unknown