Cathodic voltammetric detection of diltiazem at a bismuth film electrode: application to human urine and pharmaceuticals

Journal of the Brazilian Chemical Society

Pimenta, Adriana M.¹  Souto, M. Renata S.¹  Lopes, Joana R. T.¹  Catarino, Rita I. L.¹  Leal, M. Fernanda C.¹  University Fernando Pessoa, Porto, Portugal¹ 

关键词: bismuth film electrode;    diltiazem;    voltammetry;    pharmaceuticals;   

DOI  :  10.5935/0103-5053.20140067

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

In this work it was developed a novel application of bismuth film electrodes (BiFEs) for the determination of the antihypertensive and coronary vasodilator diltiazem by square wave cathodic voltammetry. The bismuth film was deposited ex situ on a glassy carbon electrode for 90 s at –1.4 V vs. Ag/AgCl, from an acetate buffer (pH 4.5; 0.10 mol L-1) containing 5 or 30 mg L-1 Bi. Diltiazem analytical signal was obtained in phosphate buffer (pH 7.4; 0.25 mol L-1) where reduction takes place at –1.5 V vs. Ag/AgCl. The proposed methodology was applied to the quantification of diltiazem in pharmaceutical samples (dynamic linear range comprised between 90 and 900 µg L-1) and in human urine (dynamic linear range comprised between 45 and 270 µg L-1, and detection limit of 12 µg L-1).

【 授权许可】

Unknown