Grafting amino drugs to poly(styrene-alt-maleic anhydride) as a potential method for drug release

Journal of the Brazilian Chemical Society

Kazem-Rostami, Masoud¹  Bushehr Payame Noor University, Bushehr, Iran¹  Sadeghpour, Mahdieh¹  Saien, Javad¹  Bu-Ali Sina University, Hamedan, Iran¹  Borazjani, Maryam Kiani¹  Abbasi, Fatemeh¹  Khazaei, Ardeshir¹  Islamic Azad University, Takestan, Iran¹  Saednia, Shahnaz¹ 

关键词: drug release;    polymer-drug;    poly(styrene-alt-maleic anhydride);    PSMA;    kinetic;   

DOI  :  10.5935/0103-5053.20130145

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

Drug delivery systems based on polymer-drug conjugates give an improved treatment with lower toxicity or side effects and be used for the treatment of different diseases. Conjugates of biodegradable poly(styrene-alt-maleic anhydride) (PSMA), with a therapeutic agents such as amantadine hydrochloride, amlodipine, gabapentin, zonisamide and mesalamine, were afforded by the formation of the amide bonds of the amino drugs that reacted with the PSMA anhydride groups. The amounts of covalently conjugated drugs were determined by a1 H NMR spectroscopic method, and the in vitro release rate in buffer solution (pH 1.3) was studied at body temperature 37 ºC. In kinetic studies, different dissolution models were examined to obtain drug release data and the collected data were well-fitted to the Korsmeyer-Peppas equation, revealing a dominant Fickian diffusion mechanism for drug release under the in vitro conditions.

【 授权许可】

Unknown