Monitoring of β-blockers ozone degradation via electrospray ionization mass spectrometry

Journal of the Brazilian Chemical Society

Eberlin, Marcos N¹  Nachtigall, Fabiane M¹  Santos, Leonardo S¹  Astudillo, Luis¹  Talca University, Talca, Chile¹  Quispe, Cristina¹  Alberici, Rosana M¹  Fonseca, Maria Francesca R¹  University of Campinas, Campinas, Brazil¹  Villaseñor, Jorge¹ 

关键词: ozonation;    degradation;    ESI-MS;    pharmaceutical compounds;    reaction mechanism;   

DOI  :  10.1590/S0103-50532011000500015

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

The structures of intermediate products of ozone degradation of different pharmaceutical compounds have been studied. Under the conditions employed, complete ozone degradation of nadolol was achieved after 100 min. The degradation products obtained in aqueous solution were characterized by electrospray ionization mass (and tandem mass) spectrometry (ESI-MS and ESI-MS/MS). The proposed mechanism for degradation, ozone attacks at the aniline amino group giving rise to nitro compounds and further degradation occurs via a series of oxidative processes. Continuous online monitoring by ESI-MS(/MS) with high accuracy mass measurements showed that ozone degradation of atenolol (ATE) and acebutolol (ACE) occurs via mechanisms similar to that of nadolol.

【 授权许可】

Unknown