Microwave-assisted clean synthesis of amides via aza-wittig reaction under solvent-free condition

Journal of the Brazilian Chemical Society

Nagarajan, Sangaraiah¹  Sathishkumar, Murugan¹  Dinesh, Murugan¹  Madurai Kamaraj University, Tamilnadu, India¹  Velan, Poovan Shanmuga¹  Ponnuswamy, Alagusundaram¹ 

关键词: microwave;    solution phase;    solvent-free;    amide;    aza-wittig;   

DOI  :  10.1590/S0103-50532011001100007

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

A solvent-free microwave-assisted coupling of phosphazenes with acyl chlorides or carboxylic anhydrides in presence of triethylphosphite has been accomplished resulting in a clean synthesis of amides in good yields. Unlike the prevailing time-consuming solution phase methodologies employing chlorinated solvents, benzene (carcinogenic), etc, the present protocol is an eco friendly, rapid and simple approach.

【 授权许可】

Unknown