A novel one-pot three-step synthesis of 2-(1-Benzofuran-2-yl)quinoline-3-carboxylic acid derivatives

Journal of the Brazilian Chemical Society

Zhang, Chaohua¹  Bohai University, China¹  Gao, Wentao¹  Li, Yang¹ 

关键词: one-pot;    three-step;    benzofuran;    quinoline;   

DOI  :  10.1590/S0103-50532010000500007

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

A facile and efficient one-pot three-step procedure for the preparation of 2-(1-benzofuran-2-yl)quinoline-3-carboxylic acid derivatives is described, featuring three different synthetic transformations, namely Williamson ether synthesis, hydrolysis of an ester group at the quinoline ring C-3 position, and intramolecular electrophilic cyclization reaction between the aldehyde group of salicylaldehyde and the methylene at the quinoline ring C-2 position.

【 授权许可】

Unknown