A facile synthesis of (E)-2-(aryl/hetaryl)vinyl-4-phenylquinoline-3-carboxylic acids

Heterocyclic communications

article

Wentao Gao¹  Xingpeng Li¹  Yu Wang¹  Yang Wang¹ 

[1] Institute of Superfine Chemicals, Bohai University

关键词: Arbuzov reaction;    ester hydrolysis;    Horner-Emmons olefination;    one-pot;    quinoline;    three-step;   

DOI  :  10.1515/hc-2017-0139

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

New synthetic approach to ( E )-2-aryl/hetarylvinyl-4-phenyl-quinoline-3-carboxylic acids was developed, featuring three different synthetic transformations, namely the Arbuzov reaction, in situ Horner-Emmons olefination and subsequent ester hydrolysis occurring as a one-pot procedure. The molecular structures of newly synthesized products were confirmed by spectral data and elemental analysis.

【 授权许可】

CC BY|CC BY-NC-ND