Electrochemistry of deferiprone as an orally active iron chelator and HIV-1 replication inhibitor and its determination

Journal of the Brazilian Chemical Society

Yadegari, H.¹  Jabbari, A.¹  Heli, H.¹  Majdi, S.¹  K. N. Toosi University of Technology, Tehran, Iran¹  University of Tehran, Tehran, Iran¹  Moosavi-Movahedi, A. A.¹ 

关键词: deferiprone;    anti-thalassemia drug;    platinum electrode;    iron chelator;    HIV-1 replication inhibitor;   

DOI  :  10.1590/S0103-50532008000500029

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

The electrochemical behavior of the anti-thalassemia and anti-HIV replication drug, deferiprone, was investigated by cyclic voltammetry (CV) at a platinum electrode. In an acetate buffer solution, pH = 4.0, two irreversible anodic peaks for deferiprone, with E01 = 875 mV and E02 = 1235 mV (vs. Ag/AgCl) appeared at a potential sweep rate of 50 mV s-1. Cyclic voltammetric study indicated that the oxidation process is irreversible and diffusion-controlled. The diffusion and the electron transfer coefficients of deferiprone were found to be 3.50 × 10-6 cm2 s-1 and 0.57, respectively. A sensitive, simple and time-saving differential pulse voltammetric procedure was developed. Using our proposed method, deferiprone can be determined with a detection limit of 1.43 × 10-5 mol L-1. The applicability of the method to direct assays of spiked human serum and urine fluids, and to commercial tablets, is described.

【 授权许可】

Unknown