Determination of ranitidine in drugs using a mercury coated platinum ultramicroelectrode and hanging mercury dropping electrode

Journal of the Brazilian Chemical Society

Universidade de São Paulo, São Carlos, Brazil¹  Mazo, Luiz H.¹  Malagutti, Andréa R.¹ 

关键词: Ranitidine;    square wave voltammetry;    cyclic voltammetry;    ultramicroelectrode;   

DOI  :  10.1590/S0103-50532003000200015

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

The voltammetric behavior of ranitidine has been studied in aqueous media with a mercury coated platinum ultramicroelectrode (Hg-UME) and by HMDE. The LSV curves for the electroreduction of ranitidine showed that the compound presents two reduction waves in pH < 4.0 and only one in pH > 4.0, the observed waves being attributed to the reduction of the nitro group to hydroxylamine. A linear relation between the current peak or limiting current and the ranitidine concentration using HMDE or Hg-UME was observed, demonstrating that these ultramicroelectrodes can be used in the analytical determination of ranitidine. An alternative and more sensitive methodology for the analytical determination of ranitidine by SWV was also developed, with a detection limit of 3.5 x 10-8 mol L-1 (or 11 mg L-1). The apparent recovery (AR) studies proved the accuracy and precision of the assay developed. The excipients found in comercial Antak tablets (Glaxo Wellcome) and the generic from EMSâ do not interfere in the determination.

【 授权许可】

Unknown