Synthesis and Characterization of EDTA Complexes Useful for Trace Elements Supplementation

Journal of the Brazilian Chemical Society

Wagner, Claudia C.¹  Baran, Enrique J.¹  Universidad de la República, Montevideo, Uruguay¹  Universidad Nacional de La Plata, La Plata, Argentina¹  Torre, María H.¹ 

关键词: EDTA-complexes;    IR spectra;    Raman spectra;    electronic spectra;    dissolution assays;    copper supplementation;   

DOI  :  10.1590/S0103-50532002000500006

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

Supplementation of essential trace or microtrace elements is an area of increasing interest in the field of human and veterinary pharmacology. In particular, copper supplementation is a problem of wide, strong economic and clinical impact due to the fact that a series of well-known metabolic disorders and diseases found in both humans and animals are clearly related to copper deficiencies.1-4 After iron and zinc, copper is the third most abundant transition element in the human body 2,5,6 and it plays an important series of biological functions as it is involved in electron transport (for example, plastocyanin, azurin); in oxidase systems like amine oxidase, ascorbate-oxidase, galactose oxidase and lysyl oxidase; in oxygenases like tyrosinases, in the transport of oxygen (hemocyanins); in the dismutation of the superoxide radical (superoxide dismutase) and even in iron metabolism (ceruloplasmin).2,3,5,6 There are a number of disorders related to deficiencies or to elevate copper levels in the organism. Two hereditary diseases concerning copper metabolism are particularly well-known: Wilson's disease and Menkes' syndrome. Both of them occur with a probability of about 1

【 授权许可】

Unknown