Genetic Testing for Lynch Syndrome, an Inherited Cancer of the Bowel, Endometrium, and Ovary

Reviews in Obstetrics and Gynecology

J. Craig Strafford¹ 

[1] Department of Clinical Research, and Obstetrician-Gynecologist, Holzer Health System, Gallipolis, OH

关键词: Lynch syndrome;    Colorectal cancer;    Endometrial cancer;    Ovarian cancer;    Hereditary cancer;    Familial cancer;    Cancer screening;    Genetic testing;   

DOI  :  

学科分类：医学（综合）

来源: MedReviews, LLC

【 摘 要 】

Genetic screening for the mismatch repair genes found in patients with Lynch syndrome leads to improvements in health outcomes among carriers and members of their family. Clinicians now have a simple and easily employed means of determining if an individual carries the genetic mutations found with Lynch syndrome. This article reviews the background and incidence of Lynch syndrome and presents screening criteria, including the use of Web-based algorithms to estimate the likelihood of an individual having inherited Lynch mutations. Comprehensive management plans based on individual risk and family history plus appropriate preventive measures are recommended. Primary care providers including obstetrician-gynecologists are encouraged to adopt a proactive, evidence-based approach to address patients and their relatives with Lynch syndrome.

【 授权许可】

Unknown