Reduction of MDR1, MRP1 and BCRP expression in Crohn’s disease: a role in disease pathogenesis?

Periodicum biologorum

Jergović, Mladen²  Babić, Žarko³  Vojvoda Parčina, Valerija²  Troskot, Branko¹  Bendelja, Krešo²  Mihaljević, Željko⁴  Savić Mlakar, Ana² 

[1] Department of gastroenterology, Clinical Hospital “Sisters of Charity”, School of Medicine, University of Zagreb, Croatia;Center for research and knowledge transfer in biotechnology, University of Zagreb, Croatia;Department of gastroenterology, Clinical Hospital “Dubrava”, School of Medicine, University of Zagreb, Croatia;Croatian Veterinary Institute, Zagreb, Croatia

关键词: Crohn’s disease;    ABC transporters;    MRP1 (ABCC1);    MDR1 (ABCB1);    BCRP (ABCG2);    Cytokines;    Suppressors of cytokine signaling molecules (SOCS);   

DOI  :  

学科分类：生物科学（综合）

来源: Periodicum Biologorum

【 摘 要 】

Background and purpose: ABC transporters have a non-redundant role in the maintenance of gut homeostasis and changes in their expression may contribute to the Crohn’s disease pathology. As they are closely regulated by the inflammatory...

【 授权许可】

Unknown