Evaluation of the role of ATP-binding cassette transporters as a defence mechanism against temephos in populations of Aedes aegypti

Memórias do Instituto Oswaldo Cruz

Estelita Pereira Lima¹  Marília Oliveira Fonseca Goulart¹  Modesto Leite Rolim Neto¹ 

关键词: Aedes aegypti;    ABC transporters;    resistance mechanisms;   

DOI  :  10.1590/0074-0276140164

来源: SciELO

【 摘 要 】

The role of ATP-binding cassette (ABC) transporters in the efflux of the insecticide, temephos, was assessed in the larvae of Aedes aegypti. Bioassays were conducted using mosquito populations that were either susceptible or resistant to temephos by exposure to insecticide alone or in combination with sublethal doses of the ABC transporter inhibitor, verapamil (30, 35 and 40 μM). The best result in the series was obtained with the addition of verapamil (40 μM), which led to a 2x increase in the toxicity of temephos, suggesting that ABC transporters may be partially involved in conferring resistance to the populations evaluated.

【 授权许可】

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