Different effects of phosphatidylinositol 3-kinase inhibitor LY294002 and Akt inhibitor SH-5 on cell cycle progression in synchronized HL-60 leukemia cells

Periodicum biologorum

BANFIĆ, HRVOJE¹  VIŠNJIĆ, DORA¹  LUKINOVIĆ-ŠKUDAR, Vesna¹ 

[1] Department of Physiology and Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Šalata 3, 10 000 Zagreb, Croatia

关键词: cell cycle;    phosphatidylinositol 3-kinase;    protein kinase B/Akt;    inhibitor;    HL-60;   

DOI  :  

学科分类：生物科学（综合）

来源: Periodicum Biologorum

【 摘 要 】

Background and Purpose: Pharmacological inhibitors of phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway have been proposed in treatment of leukemia. Our previous studies demonstrated that PI3K inhibitor LY294002 and Akt...

【 授权许可】

Unknown