Insulin-Dependent Transmembrane Glucose Transport in Cardiovascular Disease

Journal of Clinical and Basic Cardiology

Scherr E¹  Gasser R¹  Friehs I¹  Gasser S¹ 

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关键词: Glukose;    insuline;    Myokard;    glucose;    GLUT4;    Insulin;    myocardial;   

DOI  :  

学科分类：心脏病和心血管学

来源: Krause & Pachernegg GmbH

【 摘 要 】

In mammals, the transport of glucose across cell membranes occurs by facilitated diffusion. Several cDNAs encoding structurally related proteinswith the properties of facilitative glucose transporters have been isolated and characterized (GLUT). These molecules regulate transmembraneglucose transport in various tissues. While different types of muscle fibres contain different levels of GLUT 4 proteins and gene expression as wellas different insulin sensitivities, the nutritional state and contractile activity appear to regulate GLUT4 gene expression. While the completecascade of interactions between glucose-metabolism and hypertension has not been elucidated completely as yet, transmembrane glucose transport is certainly crucial in this setting. Glucose and high-energy metabolism play a pivotal role in the development of numerous salient characteristics of myocardial ischemia, such as the gating properties of specific ion-channels, intracellular ion-homeostasis, electrical phenomena, contractility and other phenomena. Many of these aspects of myocardial ischemia are linked in one way or the other to transmembrane glucose transport, intracellular glucose metabolism and, in fact, to GLUT4.

【 授权许可】

Unknown