Sjögren Syndrome-Related Membranous Glomerulonephritis Progressing to Membranoproliferative Glomerulonephritis

Cardiorenal Medicine

Keiichi Sumida¹  Kenichi Ohashi¹  Masahiko Oguro¹  Junichi Hoshino¹  Tatsuya Suwabe¹  Masayuki Yamanouchi¹  Kyohei Kunisawa¹  Junko Yabuuchi¹  Masahiro Kawada¹  Hiroki Mizuno¹  Akinari Sekine¹  Takeshi Fujii¹  Yoshifumi Ubara¹  Noriko Hayami¹  Naoki Sawa¹  Toshiharu Ueno¹  Eiko Hasegawa¹  Kenmei Takaichi¹ 

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关键词: Membranous glomerulonephritis;    Membranoproliferative glomerulonephritis;    Sjögren syndrome;    Hyperthyroidism;   

DOI  :  10.1159/000452298

来源: S Karger AG

【 摘 要 】

We report a case of glomerulopathy in a 36-year-old Japanese woman with primary Sjögren syndrome (pSS). The first renal biopsy suggested membranous glomerulonephritis. However, repeat biopsy was performed after 16 years because of increased proteinuria, revealing membranoproliferative glomerulonephritis with mesangial deposits, subendothelial deposits, and subepithelial deposits. Immunofluorescent studies showed predominant deposition of IgG2 and IgG4. This patient was positive for antinuclear antibody and anti-SS-A antibody. Sicca syndrome was confirmed by a positive Schirmer test and positive Rose Bengal test. Therefore, pSS-related glomerulopathy was considered to be the most likely diagnosis.

【 授权许可】

Unknown