Cardiorenal Medicine | |
Association between Glycosylated Haemoglobin Level and Contrast-Induced Acute Kidney Injury in Patients with Type 2 Diabetes Mellitus | |
Selcuk Yazici1  Sukru Akyuz1  Mehmet Karaca1  Zekeriya Nurkalem1  Tugba Kemaloglu Oz1  Baris Gungor1  Servet Altay1  Hulya Kasikcioglu1  Baris Yaylak1  Guney Erdogan1  | |
[1] $$ | |
关键词: Contrast media; Acute kidney injury; Coronary angiography; Percutaneous coronary intervention; Type 2 diabetes mellitus; | |
DOI : 10.1159/000362569 | |
来源: S Karger AG | |
【 摘 要 】
Background: There are several reports suggesting that admission hyperglycaemia increases the risk of contrast-induced acute kidney injury (CI-AKI). However, it is not clear whether there has been an association between long-standing poor glycaemic control and the incidence of CI-AKI. The purpose of this study was to examine the impact of poor glycaemic control or elevated glycosylated haemoglobin (HbA1c) on the incidence of CI-AKI in patients with type 2 diabetes mellitus (T2DM). Methods: The present study prospectively enrolled 133 patients with T2DM undergoing elective coronary angiography (CAG) and/or intervention. All patients had an estimated glomerular filtration rate (eGFR) of ≥60 ml/min/1.73 m2. Patients were divided into two groups: those with an optimal HbA1c (<7%) and those with an elevated HbA1c (≥7%). All had similar baseline characteristics and were hydrated appropriately. The outcome was assessed by the incidence of CI-AKI. Results: CI-AKI occurred in 2 of 41 patients (4.9%) with optimal HbA1c levels and 5 of 92 patients (5.4%) with elevated HbA1c levels (p = 0.89). The cutoff point of HbA1c was set at 6.5%, but no statistically significant difference between the two groups was observed [1 of 24 patients (4.1%) vs. 6 of 109 patients (5.5%), p = 0.79]. However, despite a high variability in the incidence of CI-AKI, there was no statistically significant difference between the two groups when varying CI-AKI definitions were considered. Conclusion: An elevated HbA1c level is not associated with a higher incidence of CI-AKI compared to optimal HbA1c levels in patients with T2DM (patients with an eGFR of ≥60 ml/min/1.73 m2) undergoing CAG and/or intervention.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912040509489ZK.pdf | 753KB | download |