Overnutrition and the Cardiorenal Syndrome: Use of a Rodent Model to Examine Mechanisms

Cardiorenal Medicine

Adam Whaley-Connell¹  Melvin R. Hayden¹  Lakshmi Pulakat¹  Erik J. Henriksen¹  Vincent G. DeMarco¹  James R. Sowers¹  Javad Habibi¹ 

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关键词: Overnutrition;    Zucker rat model;    Cardiorenal syndrome;    Heart/kidney disease;    Obesity;   

DOI  :  10.1159/000322827

来源: S Karger AG

【 摘 要 】

Obesity has reached epidemic proportions with far-reaching health care and economic implications. Overnutrition, characterized by excess intake of carbohydrates and fats, has been associated with end-organ damage in several tissues, including the heart and the kidney. Furthermore, overnutrition is one of the most important modifiable and preventable causes of morbidity and mortality associated with cardiovascular and kidney diseases. Insulin resistance and compensatory hyperinsulinemia as well as associated mechanisms, including enhanced renin-angiotensin-aldosterone system activity, inflammation, and oxidative stress, have been implicated in obesity-related cardiorenal injury. In this review, the effect of overnutrition on heart and kidney disease is assessed in a rodent model of overnutrition and obesity, the Zucker obese rat.

【 授权许可】

Unknown