Overnutrition and the Cardiorenal Syndrome: Use of a Rodent Model to Examine Mechanisms

Cardiorenal medicine

Adam Whaley-Connell ; Lakshmi Pulakat ; Vincent G. DeMarco ; Melvin R. Hayden ; Javad Habibi ; Erik J. Henriksen ; James R. Sowers

关键词: Overnutrition;    Zucker rat model;    Cardiorenal syndrome;    Heart/kidney disease;    Obesity;   

DOI  :  10.1159/000322827

学科分类：心脏病和心血管学

来源: S Karger AG

【 摘 要 】

Abstract Obesity has reached epidemic proportions with far-reaching health care and economic implications. Overnutrition, characterized by excess intake of carbohydrates and fats, has been associated with end-organ damage in several tissues, including the heart and the kidney. Furthermore, overnutrition is one of the most important modifiable and preventable causes of morbidity and mortality associated with cardiovascular and kidney diseases. Insulin resistance and compensatory hyperinsulinemia .

【 授权许可】

CC BY