Transfer hydrogenation reactions catalyzed by chiral half-sandwich Ruthenium complexes derived from Proline

Journal of Chemical Sciences

ASHOKA G SAMUELSON¹  ARUN KUMAR PANDIA KUMAR¹ 

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关键词: Asymmetric transfer hydrogenation;    Proline diamine ligands;    Half-sandwich ruthenium complexes;    Chiral alcohols;    Ruthenium hydride.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Chiral ruthenium half-sandwich complexes were prepared using a chelating diamine made from proline with a phenyl, ethyl, or benzyl group, instead of hydrogen on one of the coordinating arms. Three of these complexes were obtained as single diastereoisomers and their configuration identified by X-ray crystallography. The complexes are recyclable catalysts for the reduction of ketones to chiral alcohols in water. A ruthenium hydride species is identified as the active species by NMR spectroscopy and isotopic labelling experiments.Maximum enantio-selectivity was attained when a phenyl group was directly attached to the primary amine on the diamine ligand derived from proline.

【 授权许可】

Unknown