Self-assembly of a library of polyborate chiral anions for asymmetric catalytic quinoline reduction

TETRAHEDRON LETTERS

卷:56

Article

Desai, Aman A.¹  Guan, Yong¹  Odom, Aaron L.¹  Majumder, Supriyo¹  Wulff, William D.¹  Vetticatt, Mathew J.² 

[1] Michigan State Univ, Dept Chem, E Lansing, MI 48824 USA

[2] SUNY Binghamton, Dept Chem, Binghamton, NY 13902 USA

关键词: BOROX catalyst;    Quinoline;    Hantzsch ester;    Polyborate;    Boroxinate anion;    Asymmetric transfer hydrogenation;   

DOI  :  10.1016/j.tetlet.2015.02.063

来源: Elsevier

【 摘 要 】

The 'template' polyborate BOROX catalysts are shown to mediate the asymmetric transfer hydrogenation of 2-quinolines. The rapid and simple generation of a large family of BOROX catalysts with significantly altered asymmetric pockets is described. A transition state model that explains the enantioselectivity is proposed. (C) 2015 Elsevier Ltd. All rights reserved.

【 授权许可】

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