Recognition of self-assembled water-nitrate cluster in a Co(III)-2,2'-bipyridine host: Synthesis, X-ray structure, DNA cleavage, molecular docking and anticancer activity

Journal of Chemical Sciences

DHARUMADURAI DHANASEKARAN¹  ANANDAN RANJANI¹  LOGANATHAN GAYATHRI2¹  BHASKAR BISWAS1⁴  SUBHASISH SAHA2¹  JORGE PASAN²  MOHAMMAD ABDULKADER AKBARSHA³  MILAN MAJI⁵  SUBRATA DAS⁴ 

[1] Department of Microbiology, Bharathidasan University, Tiruchirappalli, Tamil Nadu 620 024, India$$;Institut de Ciencia Molecular (ICMol), Universidad de Valencia, Catedrático José Beltrán 2, 46980, Paterna, Valencia, Spain$$;Mahatma Gandhi-Doerenkamp Center, Bharathidasan University, Tiruchirappalli, Tamil Nadu 620 024, India$$;Department of Chemistry, Raghunathpur College, Purulia, West Bengal 723 133, India$$;Department of Chemistry, National Institute of Technology, Mahatma Gandhi Avenue, Durgapur, West Bengal 713 209, India$$

关键词: Cobalt(III);    Crystal structure;    Supramolecular chemistry;    Anticancer activity;    Molecular docking.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

A mononuclear cobalt(III) complex [Co(bpy)₂Cl₂]NO₃·2H₂O (1) (bpy = 2,2'-bipyridine) has been synthesized and crystallographically characterized. Self-assembly of the lattice water molecules from rectangular tetrameric water cluster interacts with nitrate anion along the c-axis forming a six membered hexagonal water-nitrate cluster. It presents a new mode of association of water molecules with nitrate molecules which is not predicted theoretically or found experimentally. The molecule effectively cleaves bacterial genomic DNA and shows important cytotoxicity against human hepatocarcinoma cell (HepG2).

【 授权许可】

Unknown