Synthesis, characterization, X-ray crystal structure, electrochemical evaluation and anti-cancer studies of a mixed ligand Cu(II) complex of (E)-N′-((2-hydroxynaphthalen-1-yl)methylene)acetohydrazide

Journal of Chemical Sciences

Iran Sheikhshoaie²  Mehdi Abbasnejad³  Maryam Mohamadi1²  Hadi Amiri Rudbari¹  Giuseppe Bruno⁴  Mahdieh Sheikhshoaie²  S Yousef Ebrahimipour1² 

[1] Department of Chemistry, University of Isfahan, Isfahan 81746-73441, Iran$$;Department of Chemistry, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran$$;Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran$$;Department of Chemical Sciences, University of Messina, Via F. Stagno d'Alcontres 31, 98166 Messina, Italy$$

关键词: Schiff base;    Cu(II) complex;    anticancer activity;    electrochemical evaluation;    crystal structure.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

A ternary mixed ligand Cu(II) complex, [Cu(L)(Phen)], was prepared from the reaction of (E)-N′-((2-hydroxynaphthalen-1-yl)methylene)acetohydrazide [HL], Cu(NO3)2.3H2O and 1,10-Phenanthroline in 1:1:1 molar ratio. This complex was fully characterized using spectroscopic and physicochemical methods. The structure of the complex was determined by single crystal X-ray diffraction. The Cu(II) center is coordinated by two oxygen and one nitrogen donors of L2− and nitrogen atoms of the heterocyclic group. Electrochemical studies of the Cu(II) complex showed shifts in the ligand peaks as well as the appearance of new peaks after complexation. The electrochemical behavior of the Cu(II) complex was also studied using cyclic voltammetry. According to biochemical investigation (MCF-7 cells viability), anticancer activity of [Cu(L)(Phen)] was higher than those of Cu(NO3)2.3H2O, HL and 1,10-Phenanthroline.

【 授权许可】

Unknown