Synthesis of 2-(oxadiazolo, pyrimido, imidazolo, and benzimidazolo) substituted analogues of 1,4-benzodiazepin-5-carboxamides linked through a phenoxyl bridge

Journal of Chemical Sciences

N Kaur1¹  D Kishore¹ 

[1] Department of Chemistry, Banasthali University, Banasthali-304022 (Rajasthan), India$$

关键词: 1;    4-benzodiazepine;    oxadiazole;    pyrimidine;    imidazole;    benzimidazole;    amidine and imidate ester.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Exceedingly facile single-step expedient protocols based on the versatility and reactivity of corresponding intermediates amidine and imidate (8 and 9), derived from 5-carboxamido-1,4-benzodiazepin-5-(4'-methylpiperazinyl)-carboxamide have been developed to provide an easy installation of the oxadiazole, pyrimidine, imidazole and benzimidazole (9-14) based privileged templates at 2-position of 5-carboxamido-1,4-benzodiazepin-5-(4'-methylpiperazinyl)-carboxamide (4), through a phenoxyl spacer, by utilizing the synthetic strategy depicted in schemes 1 and 2.

【 授权许可】

Unknown