Cytotoxic, DNA binding, DNA cleavage and antibacterial studies of ruthenium-fluoroquinolone complexes

Journal of Chemical Sciences

Hardik N Joshi¹  Chintan R Patel¹  Mohan N Patel1¹ 

[1] Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, 388 120, India$$

关键词: Ruthenium;    fluoroquinolone;    LC50;    partial intercalation;    HS DNA.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Six new Ru(II) and Ru(III) complexes have been synthesized and characterized by elemental analysis, LC-MS, electronic spectra, IR spectra and magnetic moment measurements. DNA-binding properties of Ru complexes have been studied by means of absorption spectrophotometry and viscosity measurements as well as their HS DNA cleavage properties by means of agarose gel electrophoresis. The experimental results show that all the complexes can bind to DNA via partial intercalative mode. The 𝐾b values of complexes were found in the range 2.14 × 104 to 2.70 × 105 M-1. All the complexes show excellent efficiency of cleaving DNA than respective fluoroquinolones. Brine shrimp lethality bioassay has been performed to check the cytotoxic activity. The IC50 values of the complexes are in the range of 6.27 to 16.05 𝜇g mL-1.

【 授权许可】

Unknown