Synthesis and evaluation of antimicrobial and anthelmintic activity of novel fluorinated 7-ethyl-10𝐻-phenothiazines, their sulphones and ribofuranosides

Journal of Chemical Sciences

Naveen Gautam1¹  Nishidha Khandelwal2²  D C Gautam2²  Abhilasha Yadav2² 

[1] LBS Government PG College, Kotputli, Jaipur 303 108, India$$;Department of Chemistry, University of Rajasthan, JLN Marg, Jaipur 302 004, India$$

关键词: 10𝐻-phenothiazines;    Smiles rearrangement;    sulphones;    ribofuranosides;    antimicrobial activity;    anthelmintic activity.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

A series of novel fluorinated 10𝐻-phenothiazines were synthesized via Smiles rearrangement. 10𝐻-phenothiazines on refluxing with 30% hydrogen peroxide in glacial acetic acid gave 10𝐻-phenothiazines-5, 5-dioxides (sulphones). These synthesized 10𝐻-phenothiazines were then used as base to prepare ribofuranosides by treating them with sugar (𝛽-D-ribofuranosyl- 1-acetate-2, 3, 5-tribenzoate). The synthesized compounds were screened for antimicrobial activity and anthelmintic activity. The structural assignments of compounds were made on the basis of spectroscopic data and elemental analysis.

【 授权许可】

Unknown