An efficient synthesis and biological study of substituted 8-chloro-5-methoxy/8-chloro-4H-1,4-benzothiazines, their sulphones and ribofuranosides

Journal of Chemical Sciences

D C Gautam1¹  Naveen Gautam1¹  Abhilasha1¹  Nishidha Khandelwal1¹ 

[1] Department of Chemistry, University of Rajasthan, Jawahar LaL Nehru Marg, Jaipur 302 004, India$$

关键词: 4H-1;    4-benzothiazines;    sulphones;    ribofuranosides;    antimicrobial activity;    anthelmintic activity.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

8-Chloro-5-methoxy/8-chloro-4H-1,4-benzothiazines were synthesized by condensation followed by oxidative cyclisation of 2-amino-6-chloro-3-methoxy/2-amino-3-chlorobenzenethiol with 𝛽-diketones/𝛽-ketoesters in the presence of dimethyl sulphoxide. By treating 4H-1,4-benzothiazines with 30% hydrogen peroxide in glacial acetic acid, 4H-1,4-benzothiazine-1,1-dioxides (sulphones) were synthesized. The 4H-1,4-benzothiazines have also been used as a base to prepare ribofuranosides by the reaction with 𝛽-D-ribofuranose-1-acetate-2,3,5-tribenzoate. All the synthesized compounds have been characterized by spectral and elemental analysis and have been examined for antimicrobial and anthelmintic activity.

【 授权许可】

Unknown