Supported 𝐿-pyrrolidine-2-carboxylic acid-4-hydrogen sulphate on silica gel as an economical and efficient catalyst for the one-pot preparation of 𝛽-acetamido ketones via a four-component condensation reaction

Journal of Chemical Sciences

Arash Ghorbani-Choghamarani1¹  Parisa Zamani¹ 

[1] Department of Chemistry, Faculty of Science, Ilam University, P.O. Box 69315516, Ilam, Iran$$

关键词: 𝛽-Acetamido ketones;    𝐿-pyrrolidine-2-carboxylic acid-4-hydrogen sulphate;    one-pot;    four-component;    catalyst.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

An efficient, one-pot, four-component condensation of aldehydes, acetophenone (or propiophenone), acetyl chloride and acetonitrile in the presence of catalytic amounts of 𝐿-pyrrolidine-2-carboxylic acid-4-hydrogen sulphate (supported on silica gel), a green and non-toxic catalyst, is described for the preparation of 𝛽-acetamido ketones in good to excellent yields.

【 授权许可】

Unknown