Synthesis and evaluation of some novel precursors of oxazolidinone analogues of chloroquinoline for their antimicrobial and cytotoxic potential

Journal of Chemical Sciences

Kavita Devi¹  Swapnil Sharma2²  Yumna Asmat¹  Jaya Dwivedi¹  Meenakshi Agrawal¹ 

[1] Department of Chemistry, Banasthali University, Banasthali 304 022, India$$;Department of Pharmacy, Banasthali University, Banasthali 304 022, India$$

关键词: Synthesis;    4-7-dichloroquinoline;    1-3-diaminopropane;    oxazolidinone;    antimicrobial activity and cytotoxicity study.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Some 3-(3-(7-chloroquinolin-4-ylamino)propyl-2-imino-5-(4-chloro/nitro/methoxy benzylidene) oxazolidin-4-one 4(a-c) and 4-(3-(7-chloroquinolin-4-ylamino) propyl)-2(4-chloro/nitro/methoxy benzylidene)-1,6-diox-4,9 diazaspiro[4,4]nonane-3,8-dione 5(a-c) derivatives were synthesized using appropriate synthetic route. The newly prepared compounds 5a-c demonstrated inhibitory effects on the growth of a MCF7 (hormone-dependant breast carcinoma cell line), HT29 (colon carcinoma cell line on leukemia). The MCF7 cell line was found to be very susceptible towards compound 5a with IC50 values of 16 𝜇g/ml. Similarly, the HT29 cell line was found to be moderately susceptible towards compounds 5a and 5c with IC 50 values of 32 and 49 𝜇g/ml, respectively.

【 授权许可】

Unknown