A Novel Synthesis of the Oxazolidinone Antithrombotic Agent Rivaroxaban

Molecules

Jianyong Yuan¹  Kai Liu¹  Lun Li¹  Yong Yuan¹  Xuelei Liu¹ 

[1] Pharmacy College, Chongqing Medical University, Chongqing 400016, China;

关键词: rivaroxaban;    oxazolidinone;    Goldberg coupling reaction;   

DOI  :  10.3390/molecules190914999

来源: mdpi

【 摘 要 】

A facile synthetic route of rivaroxaban has been developed. Using commercially available (R)-epichlorohydrin and bromobenzene as the starting materials, rivaroxaban was obtained in 39% overall yield using a Goldberg coupling as the key step. The synthetic route represents a convenient procedure for the production of rivaroxaban.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.