New and rapid access to synthesis of novel polysubstituted imidazoles using antimony trichloride and stannous chloride dihydrate as effective and reusable catalysts

Journal of Chemical Sciences

Leyla Poorali¹  Khalil Eskandari²  Mahboobeh Azizi¹  Bahador Karami2² 

[1] Department of Chemistry, Gachsaran Branch, Islamic Azad University, Gachsaran, 75817-75785, Iran$$;Department of Chemistry, Yasouj University, Yasouj, 75918-74831 P.O. Box 353, Iran$$

关键词: Benzil;    polysubstituted imidazoles;    aldehydes;    amines;    heterogeneous catalyst.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

In this work, new, efficient and environmentally adapted synthesis of polysubstituted imidazoles in one-pot is repoted. The multicomponent reaction of various aldehydes, benzil, aliphatic and aromatic primary amines and ammonium acetate under solvent-free condition is explained. The highly efficient role of antimony trichloride and stannous chloride dihydrate as catalyst in this synthesis was shown and their effects on the reaction process were studied. By this advantage, several polysubstituted imidazoles as pharmaceutical important molecules can be prepared in high yield and high purity. This method is a very easy and rapid for the synthesis of imidazole derivatives.

【 授权许可】

Unknown