Synthesis and evaluation of some bioactive compounds having oxygen and nitrogen heteroatom

Journal of Chemical Sciences

Nalini V Purohit2¹  Poonam Yadav² 

[1] Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390 002, India$$;School of Science and Education, Navrachana University, Vadodara 391 410, India$$

关键词: Pyrazole isocoumarins;    Schiff base isocoumarins;    antibacterial activity;    antifungal activity;    analgesic activity.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Some new 3,4-disubstituted isocoumarins were synthesized having bioactive pyrazole molecule at 3rd position of isocoumarin moiety (5a,b), from isocoumarin -3- carboxylic acid hydrazide (4a,b) followed by cyclization with acetyl acetone. A series of isocoumarin derivative having Schiff base as lateral side chain at 3rd position of isocoumarin moiety were also synthesized (7a,b), by condensing isocoumarin acid hydrazide and benzaldehyde derivative followed by dehydration. The chemical structures of all the compounds were determined by analytical and spectral method. The lead compounds were screened for antimicrobial and analgesic activities.

【 授权许可】

Unknown