Synthesis, characterization and biological evaluation of thiazolopyrimidine derivatives

Journal of Chemical Sciences

I M Khazi¹  H Nagarajaiah²  Noor Shahina Begum1² 

[1] Department of Chemistry, Karnatak University, Dharwad 580 003, India$$;Department of Chemistry, Bangalore University, Bangalore 560 001, India$$

关键词: 3;    4-Dihydropyrimidine 2-thione;    thiazolopyrimidine;    crystal structure;    antibacterial and antifungal activity.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Different substituted diesters of thiazolopyrimidine were prepared by the treatment of 3,4 dihydropyrimidine2-thione with 𝛼-haloesters using ethanol under reflux condition affording 71-85% yield. IR, 1HNMR, 13CNMR and elemental analyses were used for the characterization of these compounds. The crystal and molecular structure of one of the product, 5-phenyl-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidine-2,6-dicarboxylic acid diethyl ester (3e) was verified by single crystal X-ray diffraction method. The antimicrobial activity was evaluated against four bacterial strains and one fungal species. Few of the derivatives exhibited antibacterial and antifungal activities.

【 授权许可】

Unknown