Journal of Chemical Sciences | |
Synthesis, characterization and biological evaluation of thiazolopyrimidine derivatives | |
I M Khazi1  H Nagarajaiah2  Noor Shahina Begum12  | |
[1] Department of Chemistry, Karnatak University, Dharwad 580 003, India$$;Department of Chemistry, Bangalore University, Bangalore 560 001, India$$ | |
关键词: 3; 4-Dihydropyrimidine 2-thione; thiazolopyrimidine; crystal structure; antibacterial and antifungal activity.; | |
DOI : | |
来源: Indian Academy of Sciences | |
【 摘 要 】
Different substituted diesters of thiazolopyrimidine were prepared by the treatment of 3,4 dihydropyrimidine2-thione with ð›¼-haloesters using ethanol under reflux condition affording 71-85% yield. IR, 1HNMR, 13CNMR and elemental analyses were used for the characterization of these compounds. The crystal and molecular structure of one of the product, 5-phenyl-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidine-2,6-dicarboxylic acid diethyl ester (3e) was verified by single crystal X-ray diffraction method. The antimicrobial activity was evaluated against four bacterial strains and one fungal species. Few of the derivatives exhibited antibacterial and antifungal activities.
【 授权许可】
Unknown
【 预 览 】
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